Therapeutically active 3-fluoro-10-piperazino-8- substituted...

Details Therapeutically active 3-fluoro-10-piperazino-8- substituted... Therapeutically active 3-fluoro-10-piperazino-8- substituted...

C - Chemistry, Metallurgy

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C07D 409/04 (2006.01) C07C 17/093 (2006.01) C07C 17/14 (2006.01) C07C 51/08 (2006.01) C07D 295/00 (2006.01) C07D 295/073 (2006.01) C07D 295/088 (2006.01) C07D 295/092 (2006.01) C07D 295/205 (2006.01) C07D 337/14 (2006.01)

Patent

CA 1100134

ABSTRACT OF THE DISCLOSURE: 3-Fluoro-10-piperazino-8-substituted 10,11-dihydro- dibenzo[b,f]thiepins having the general formula: Image (I) and their pharmaceutically acceptable acid addition salts, wherein: R1 represents an alkyl group having 2 or 3 carbon atoms, a hydroxyl, ethoxyl, ethylthio, nitro, amino or cyano group, an aminocarbonyl or an acyl group having from 1 to 3 carbon atoms, and R2 represents a hydrogen atom, an alkyl group having from 1 to 3 carbon atoms, a hydroxyalkyl group having 2 or 3 carbon atoms, an acyloxyalkyl group having a total number of 4 to 20 carbon atoms, in which the acyl moiety is a rest of an aliphatic or aromatic acid, a cyclic acetal radical of the formula: Image in which R represents a hydrogen atom or a methyl group and n is 1 or 2, or R2 represents a p-fluorophenylaliphatic radical of the formula: Image in which m is 1, 2 or 3 and X is a direct bond, an oxygen or sulfur atom, a carbonyl group or a bivalent radical of the formula: Image are therapeutically active, showing psychotropic activity at an acceptable level of toxicity. They are neuroleptics with a high degree of the cataleptic, anti-apomorphine and central depressant action.

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