Therapeutically active .alpha.-msh analogues

Details Therapeutically active .alpha.-msh analogues Therapeutically active .alpha.-msh analogues

C - Chemistry, Metallurgy

07

K

C07K 14/685 (2006.01) A61K 38/34 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2620228

The invention describes peptide analogues of a-melanocyte-stimulating hormone (a-MSH), which posses an increased efficay compared to the native .alpha.-MSH peptide. The .alpha.-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to .alpha.- MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.

L'invention a pour objet des analogues peptidiques de l~hormone stimulatrice des mélanocytes de type .alpha. (.alpha.-MSH), qui possèdent une efficacité augmentée comparé au peptide .alpha.-MSH natif. Les analogues .alpha.-MSH présentent des effets anti-inflammatoires augmentés et une capacité augmentée de prévention des conditions d'ischémie par rapport à l~.alpha.-MSH. L'invention concerne en outre l~utilisation de peptides pour la fabrication de compositions pharmaceutiques pour le traitement ou la prophylaxie d'une condition dans le tissu d'un ou plusieurs organes d'un mammifère, et de plus des compositions pharmaceutiques.

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