Therapeutically active substituted dibenzyl ethers

Details Therapeutically active substituted dibenzyl ethers Therapeutically active substituted dibenzyl ethers

C - Chemistry, Metallurgy

07

D

260/315.25

C07D 233/64 (2006.01) C07C 29/143 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1115718

ABSTRACT Therapeutically Active Substituted Dibenzyl Ethers There are provided 2,4-dichloro-4'-phenyl-.alpha.-(N-imidazolyl- -methyl)-dibenzyl ether, 2,4-dichloro-4'-phenylthio-.alpha.- -(N-imidazolyl-methyl)-dubenzyl ether and pharmaceutically acceptable acid addition salts thereof. These compounds show activity against some fungi, yeasts and gram positive aerobic and anaerobic bacteria. The new compounds can be prepared by condensing 1-(2',4'- -dichlorophenyl)-2-(N-imidazolyl-methyl)-ethanol with 4-chloromethyl-biphenyl), 4-bromomethyl-biphenyl, 1-phenylthio-4-chloromethyl-benzene or 1-phenylthio-4- -bromomethyl-benzene in a solvent, most preferably dimethylsulphoxide.

327426

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