Therapeutically effective 1.alpha., 25-dihydroxyvitamin d3...

Details Therapeutically effective 1.alpha., 25-dihydroxyvitamin d3... Therapeutically effective 1.alpha., 25-dihydroxyvitamin d3...

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/575 (2006.01) A61K 31/593 (2006.01) A61P 3/02 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 19/10 (2006.01) A61P 25/28 (2006.01) C07C 35/21 (2006.01) C07C 39/23 (2006.01) C07J 9/00 (2006.01)

Patent

CA 2304056

Novel analogs of 1.alpha., 25-dihydroxyvitamin D3, which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which 1.alpha., 25- dihydroxyvitamin D3 or its prodrugs are involved. Novel analogs have general formulae represented by compounds of groups I-V. A method for treatment and prevention of diseases connected with the endocrine system.

L'invention concerne de nouveaux analogues de 1.alpha.,25-dihydroxyvitamine D¿3?, qui sont des agonistes sélectifs des réponses génomiques ou des agonistes ou des antagonistes des réponses cellulaires rapides pour une large palette de maladies dans lesquelles sont impliqués la 1.alpha.,25-dihydroxyvitamine D¿3? ou ses promédicaments. Ces nouveaux analogues ont des formules générales représentées par les composés des groupes I-V. L'invention concerne également une méthode de traitement et de prévention des maladies liées au système endocrinien.

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