Therapeutically useful 1-alkyl-2-aminotetralin derivatives

Details Therapeutically useful 1-alkyl-2-aminotetralin derivatives Therapeutically useful 1-alkyl-2-aminotetralin derivatives

C - Chemistry, Metallurgy

07

C

260/469.4, 260/4

C07C 15/00 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/235 (2006.01) C07C 5/10 (2006.01) C07C 215/64 (2006.01)

Patent

CA 1236113

Abstract Compounds of the formula Image wherein R3 and the NR1R2 group are in a cis-position to each other and wherein Y is OH, R4COO, (R5)2NCOO or R6O either in position 5 or position 7, whereby R4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R5 is an alkyl group having 1-5 carbon atoms and R6 is an allyl or benzyl group, R1 is hydrogen or an alkyl group having 1-3 carbon atoms, R2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenyl- alkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharma- ceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

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