C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/04 (2006.01) A61K 31/395 (2006.01) C07C 45/46 (2006.01) C07C 45/59 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 311/16 (2006.01) C07D 295/033 (2006.01) C07D 295/073 (2006.01) C07D 295/096 (2006.01) C07D 295/155 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2090321
This invention is therapeutically useful 2-aminotetralins and pharmaceutically acceptable acid addition salts thereof of for- mula (I), wherein R is hydrogen or halogen, wherein R1 is hydrogen, OR4, SR4, CONR5R6, CN, het, C(O)het, CF3, SO2NR5R6, 5-oxazolyl, CSNR5R6, OSO2CF3, wherein R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, (CH2)m-cycloalkyl; (CH2)m-cycloalkenyl, (CH2)m-aryl, (CH2)m-CO2R4, (CH2)m-OR4, wherein R4, R5 and R6 are independ- ently hydrogen, alkyl, alkenyl, cycloalkyl, and wherein X is (CH2)n, m = 0-4, n = 4-8, p = 0,1. These compounds are use- ful to treat central nervous system disorders, hypertension, diabetes, sexual impotency and to control appetite.
Darlington William H.
Haadsma Susanne R.
Lin Chiu-Hong
Piercey Montford F.
Romero Arthur G.
Macrae & Co.
Pharmacia & Upjohn Company
The Upjohn Company
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