Therapeutically useful alkylbenzylidene derivatives

C - Chemistry – Metallurgy – 07 – C

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260/552, 260/515

C07C 49/835 (2006.01) C07C 45/54 (2006.01) C07C 49/83 (2006.01)

Patent

CA 1204774

- 28 - ABSTRACT Benzylidene derivatives of the general formula: Image wherein n represents an integer from 1 to 12, R1 represents a straight- or branched-chain alkyl or alkenyl radical having 2 to 6 carbon atoms, R2 represents an amino radical, a hydroxy radical, or a group -OM in which M represents an alkali metal or alkaline earth metal, and X1, X2 and X3 each represent, independently of one another, a hydrogen atom, the methoxy radical or straight- or branched-chain alkyl radical having 1 to 4 carbon atoms, are new compounds useful in therapy, more particularly as antidepressants, anticonvulsants, ulcer inhibitors and gastric secretion inhibitors and also as anxiolytic, analgesic and anti- inflammatory agents. They can be prepared inter alia by reacting a corresponding appropriately-substituted benzophenone with a compound H2N-(CH2)n-COR2, n and R2 being as defined above.

442044

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