C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2278102
The present invention relates to exogenous mutant HSF (mutHSF encoded by exogenous DNA) alters expression or synthesis of endogenous heat shock protein (hsp) genes in eukaryotic cells, tissues and organisms (e.g., mammalian, particularly human, cells, tissues and organisms). As described herein, mutHSF has been shown to regulate expression of endogenous hsp in cells and, as a result, to alter the response of the cells to stress. The mutHSF of the present invention is either positively-acting mutHSF or negatively-acting mutHSF.
La présente invention concerne un facteur de transcription de choc thermique mutant exogène (mutHSF codé par un ADN exogène) altérant l'expression ou la synthèse de gènes d'une protéine de choc thermique (hsp) endogène dans des cellules, des tissus et des organismes eucaryotes (par exemple des cellules, des tissus et des organismes de mammifères et notamment, d'humains). Dans le procédé selon l'invention, mutHSF régule l'expression d'une hsp endogène dans des cellules, et, ensuite, altère la réponse des cellules au stress. Le mutHSF de la présente invention est soit un mutHSF agissant positivement, soit un mutHSF agissant négativement.
Gowling Lafleur Henderson Llp
The University Of Miami
LandOfFree
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