C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/40 (2006.01) G01N 33/573 (2006.01) C12N 9/54 (2006.01)
Patent
CA 2648947
The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumour cells, the method comprising the administration of a Cathepsin S inhibitor to said cells. Also provided is a therapy comprising an anti Cathepsin S antibody, in particular an anti-Cathepsin S antibody which does not inhibit the proteolytic effect of Cathepsin S but nevertheless inhibits angiogenesis and a combination treatment comprising a Cathepsin S inhibitor and a therapeutic agent.
L'invention porte sur un procédé d'inhibition de la régulation à la hausse de la Cathepsine S à la surface de cellules tumorales sous l'effet d'une chimiothérapie, consistant à administrer un inhibiteur de la Cathepsine S auxdites cellules. L'invention porte également: sur une thérapie utilisant un anticorps de la Cathepsine S en particulier un anticorps n'inhibant pas l'effet protéolytique de la Cathepsine S mais inhibant néanmoins l'agiogenèse; et sur un traitement combiné associant un inhibiteur de la Cathepsine S et un agent thérapeutique.
Burden Roberta
Gormley Julie
Johnston James
Mcmeel Darragh
Olwill Shane
Fusion Antibodies Limited
Gowling Lafleur Henderson Llp
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