C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/70 (2006.01) C12N 5/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/34 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2135648
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telom- erase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing the loss of telomeric repeats in aging cells.
Blackburn Elizabeth H.
Shay Jerry
West Michael D.
Wright Woodring
Board Of Regents The University Of Texas System
Smart & Biggar
The Board Of Regents Of The University Of Texas System
The Regents Of The University Of California
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