Therapy for disorders of the proximal digestive tract

Details Therapy for disorders of the proximal digestive tract Therapy for disorders of the proximal digestive tract

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/196 (2006.01) A61K 31/405 (2006.01) A61K 31/415 (2006.01) A61K 31/4172 (2006.01) A61K 31/4174 (2006.01) A61K 31/426 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2717660

A method for managing or treating an in-flammatory, erosive, dyspeptic or reflux disorder of the proximal digestive tract of a subject comprises administer-ing to the subject a therapeutically effective amount of an ACE2 inhibitor. A therapeutic combination, useful to treat any disease or condition in which an NSAID is indicated, comprises an NSAID in an anti-inflammatory, analgesic or antipyretic effective amount and a gastroprotective agent that comprises an ACE2 inhibitor in an amount ef-fective to protect mucosal surfaces of the proximal diges-tive tract from erosion or ulceration induced by the NSAID.

La présente invention concerne un procédé permettant de gérer ou traiter un trouble inflammatoire, érosif, dyspeptique ou de reflux affectant le tube digestif proximal d'un sujet, et consistant en l'administration à ce sujet d'une quantité thérapeutiquement efficace d'un inhibiteur d'ACE2. On utilise à cet effet une combinaison thérapeutique permettant de traiter toute affection ou tout état dans lesquels les anti-inflammatoires non stéroïdiens sont indiqués. Cette combinaison comprend, d'une part un anti-inflammatoire non stéroïdien en quantité suffisante pour avoir une action anti-inflammatoire, analgésique ou antipyrétique, et d'autre part un agent gastroprotecteur comprenant un inhibiteur d'ACE2 en quantité suffisante pour protéger les surfaces muqueuses du tube digestif proximal contre l'érosion ou l'ulcération induite par l'anti-inflammatoire non stéroïdien.

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