C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/866 (2006.01) A61K 35/64 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2368427
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurrence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting various forms of cancer.
L'invention concerne des compositions et procédés pour utiliser des cellules d'insectes comprenant des protéines et des peptides non exprimés en surface codant des baculovirus. L'invention concerne notamment des compositions comprenant des cellules d'insectes contenant des baculovirus qui expriment les cytokines. Ces compositions peuvent être administrées, par exemple, par injection directe intratumorale dans des tumeurs de mammifères, ce qui mène à la réduction ou à la résorption des tumeurs. Dans un autre aspect, l'invention concerne des procédés destinés à améliorer la résistance à l'apparition répétitive de tumeurs chez les mammifères qui ont manifesté cette résorption de tumeurs. Dans un aspect spécifique de cette invention, les mammifères sont des sujets humains présentant différentes formes du cancer.
Dhong Zhongyun
Fidler Isaiah J.
Lu Weixin
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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