Therapy targeting cancer stem cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/0784 (2010.01) C12N 5/095 (2010.01) A61K 31/519 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) C40B 40/02 (2006.01)

Patent

CA 2731091

Disclosed herein are new immunotherapy methods that involve the isolation of cancer stem cells from tumor tissue and use of the cells either directly or indirectly through proteins or other factors associated with the cells to activate antigen presenting cells. The activated antigen presenting cells are useful as a therapy against the tumor. Also disclosed herein are novel methods of isolating and characterizing cancer stem cells and producing individual cancer stem cell lines. Dendritic cell lines are also disclosed herein.

La présente invention concerne de nouveaux procédés d'immunothérapie, qui impliquent l'isolation de cellules souches cancéreuses depuis une tumeur affectant des tissus et l'utilisation de ces cellules directement ou indirectement, par des protéines ou d'autres facteurs associés aux cellules, pour activer des cellules de présentation des antigènes. Les cellules de présentation des antigènes activées sont utiles en tant que thérapie contre la tumeur. L'invention porte également sur de nouveaux procédés d'isolation et de caractérisation de cellules souches cancéreuses, et sur la production de lignées de cellules souches cancéreuses individuelles. L'invention concerne par ailleurs des lignées de cellules dendritiques.

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