Therapy via targeted delivery of nanoscale particles

Details Therapy via targeted delivery of nanoscale particles Therapy via targeted delivery of nanoscale particles

A - Human Necessities

61

K

A61K 41/00 (2006.01) A61K 51/02 (2006.01) A61N 1/40 (2006.01) A61N 2/02 (2006.01) A61P 35/00 (2006.01) H01F 1/00 (2006.01) A61K 9/14 (2006.01)

Patent

CA 2543923

Disclosed are compositions, systems and methods for treating a subject's body, body part, tissue, body fluid cells, pathogens, or other undesirable matter involving the administration of a targeted thermotherapy that comprises a bioprobe (energy susceptive materials that are attached to a target-specific ligand). Such targeted therapy methods can be combined with at least one other therapy technique. Other therapies include hyperthermia, direct antibody therapy, radiation, chemo- or pharmaceutical therapy, photodynamic therapy, surgical or interventional therapy, bone marrow or stem cell transplantation, and medical imaging, such as MRI, PET, SPECT, and bioimpedance. The disclosed therapies may be useful in the treatment of a variety of indications, including, but not limited to, cancer of any type, such as bone marrow, lung, vascular, neuro, colon, ovarian, breast and prostate cancer, epitheleoid sarcomas, AIDS, adverse angiogenesis, restenosis, amyloidosis, tuberculosis, cardiovascular plaque, vascular plaque, obesity, malaria, and illnesses due to viruses, such as HIV.

L'invention concerne des compositions, des systèmes et des méthodes pour traiter le corps d'un patient, une partie du corps, des tissus, des cellules du liquide corporel, des pathogènes ou toute autre matière non désirable comprenant l'administration d'une thermothérapie cible comprenant une biosonde (matières sensibles à l'énergie fixées à un ligand à cible spécifique). Lesdites méthodes de thérapie cibles peuvent être associées à au moins une autre technique de thérapie. D'autres thérapies comprennent l'hyperthermie, la thérapie directe d'anticorps, les rayons, la chimiothérapie ou la thérapie pharmaceutique, la thérapie photodynamique, une thérapie chirurgicale ou d'intervention, des greffes de cellules souches ou de moelle osseuse, et de l'imagerie médicale telle que l'IRM, la TEP, la tomographie d'émission monophotonique et la bioimpédance. Les thérapies de l'invention peuvent être utilisées dans le traitement d'une pluralité d'indications, notamment le cancer de nombreux types, tel que le cancer de la moelle osseuse, des poumons, des artères, des neurones, du colon, des ovaires, du sein et de la prostate, les sarcomes de l'épithéléoide, le SIDA, l'angiogénèse inverse, la resténose, l'amyloidose, la tuberculose, la plaque cardiovasculaire et vasculaire, l'obésité, la malaria, et des maladies associées à des virus, tels que le VIH.

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