A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/576 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2238879
Activation of cells bearing CD40 on their cell surface by CD40 ligand is inhibited by contacting the cells with an agent capable of inhibiting interaction between CD40 ligand and the cells, in an amount effective to inhibit activation of the cells. Activation of cells bearing CD40 on their surface by CD40 ligand in a subject is inhibited by administering to the subject an agent capable of inhibiting interaction between CD40 ligand and the cells, in an amount effective to inhibit activation of the cells. Conditions dependent on CD40 ligand-induced activation of CD40-bearing cells are treated.
L'activation de cellules portant la molécule CD40 sur leur surface par le ligand de CD40 (CD40-L) est inhibée en mettant les cellules en contact avec un agent capable d'inhiber l'interaction entre CD40-L et les cellules. L'activation des cellules portant la molécule CD40 sur leur surface par CD40-L est inhibée chez un sujet en lui administrant une quantité suffisante d'un agent capable d'inhiber l'interaction entre CD40-L et les cellules. Ceci permet de traiter les troubles liés à l'activation de cellules portant la molécule CD40, par CD40-L.
Chess Leonard
Karpusas Mihail N.
Lederman Seth
Thomas David W.
Yellin Michael J.
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
The Trustees Of Columbia University In The City Of New York
LandOfFree
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