C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/40 (2006.01) B01L 3/00 (2006.01) B01L 9/00 (2006.01) C12M 1/36 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2395941
An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A heated cover deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.
Atwood John G.
Goven Lisa M.
Leath Richard
Margulies Marcel
Mossa Albert C.
Borden Ladner Gervais Llp
Perkin-Elmer/cetus Instruments
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