Thermally-targeted delivery of medicaments, including...

Details Thermally-targeted delivery of medicaments, including... Thermally-targeted delivery of medicaments, including...

A - Human Necessities

61

K

A61K 38/17 (2006.01)

Patent

CA 2643075

Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat protein, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) spacer and a cysteine residue conjugated to therapeutic such as doxorubicin, or a analog thereof.

L'invention concerne un polypeptide de type élastine (ELP) utilisé comme vecteur pour l'administration thermiquement ciblée de substances thérapeutiques, notamment des médicaments chimiothérapeutiques cytotoxiques comme la doxorubicine. Des exemples d'un vecteur à base d'ELP peuvent comprendre: 1) un peptide de pénétration cellulaire, tel qu'une protéine Tat; 2) ELP; et 3) l'espaceur glycyl-phényl-alanyl-leucyl-glycine (GFLG) dégradable par les lyposomes, et un résidu de cystéine conjugué à une substance thérapeutique comme la doxorubicine ou son analogue.

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