Thermo-kinetic mixing for pharmaceutical applications

Details Thermo-kinetic mixing for pharmaceutical applications Thermo-kinetic mixing for pharmaceutical applications

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01)

Patent

CA 2697099

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

L'invention concerne des compositions et des procédés de préparation d'une forme galénique pharmaceutique comprenant la préparation d'une composition pharmaceutique qui comprend un ou plusieurs ingrédients pharmaceutiques actifs (API) avec un ou plusieurs excipients pharmaceutiquement acceptables par combinaison thermocinétique en un composite. L'invention concerne également des compositions et des procédés de prétraitement d'un composite comprenant un ou plusieurs API avec un ou plusieurs excipients comprenant la combinaison thermocinétique, comprenant le traitement thermocinétique des API avec les excipients en un composite, le composite pouvant être en outre traité par des procédés classiques connus dans l'art, tels qu'une extrusion thermofusible, une granulation en fusion, un moulage par compression, une compression de comprimé, un remplissage de capsule, un revêtement de film ou un moulage par injection.

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