C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/311.9
C07D 261/08 (2006.01) C07D 498/10 (2006.01)
Patent
CA 1137493
ABSTRACT OF THE DISCLOSURE This invention provides a process for preparing 2-(3-aryl-5-isoxazolyl)-benzoic acid having the formula Image wherein X and Y are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, halo-lower-alkyl, phenoxyphenyl and cyano which comprises heating 3'-(aryl)spiro[isobenzofuran-1(3H),5'(4'H)-isoxazol] 3-one having the formula Image at a temperature ranging from 30°C. to the reflux temperature of the solution. The compounds obtained are effective as plant growth regulants. The process of the present inven- tion overcomes disadvantages associated with prior art processes which involve the conversion of isoxazolin-5-yl benzoate with N-bromosuccinimide or dichlorodicyanobenzo- quinone since isoxazolin-5-yl benzoates are prepared from vinyl benzoates which are difficult to prepare.
346196
Howe Robert K.
Liu Kou C.
Mcfadden Fincham
Monsanto Company
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