Thermophilic organisms for conversion of lignocellulosic...

Details Thermophilic organisms for conversion of lignocellulosic... Thermophilic organisms for conversion of lignocellulosic...

C - Chemistry, Metallurgy

12

P

C12P 7/06 (2006.01)

Patent

CA 2627191

Mutant thermophilic organisms that consume a variety of biomass derived substrates are disclosed herein. Strains of Thermoanaerobacterium saccharolyticum with acetate kinase and phosphotransacetylase expression eliminated are disclosed herein. Further, strain ALKl has been engineered by site directed homologous recombination to knockout both acetic acid and lactic acid production. Continuous culture involving a substrate concentration challenge lead to evolution of ALKl , and formation of a more robust strain designated ALK2. Both organisms produce near theoretical ethanol yields without expressing pyruvate decarboxylase

L'invention porte sur des organismes thermophiles mutants consommant différents substrat dérivant de biomasses. Et en particulier sur des souches de Thermoanaerobacterium saccharolyticum dans lesquelles on a supprimé la possibilité d'exprimer l'acétate kinase et la phosphotransacétylase. En outre, la souche ALK1 obtenue par recombinaison homologue à orientation sur un site bloque la production de l'acide lactique et de l'acide acétique. Une culture continue à conflit de concentration du substrat entraîne une évolution de l'ALKI, et la formation de souches plus robustes dites AKK2. Les deux organismes donnent des rendements en éthanol quasi théoriques tout en évitant l'expression de pyruvate décarboxylase

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