A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/34 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01) A61L 26/00 (2006.01) A61L 29/08 (2006.01) A61K 7/42 (1990.01)
Patent
CA 2085690
ABSTRACT Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation There is disclosed a thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation having improved thermo-rheological properties and with a gel- ling temperature interval between about 25 °C and 37 °C, which comprises a) 10 to 30 wt.% of block copolymers of a-hydro-.omega.-hydroxypoly(oxyethylene)/ poly(oxypropylene)/poly(oxy-ethylene) (Poloxamer) of the formula H(OCH2CH2)a (OCHCH2)b (OCH2CH2)aOH CH3 wherein a is at least 2 and b is at least 15 and the total portion of hydrophilic polyethylene units amounts to from 20 to 90 wt.% of the copolymer having a molecular weight from 1000 to above 16000; b) 0.01 to 5 wt.% of carboxyvinyl polymer (carbomer) having a molecular weight from l x 106 to 4 x 106; c) such an amount of a pharmaceutically acceptable base as necessary for adjusting the pH to a value between 4 and 8; d) 20 to about 85 wt.% of water, and e) optionally usual auxiliary agents. There is also disclosed a liquid galenic formulation containing a therapeutically active amount of an active substance and a thermoreversible gel as a liquid pharmaceutical carrier, the active substance being selected from the group consisting of .beta.-lactamic antibiotics and other antibacterial agents, chemotherapeutics, antiinfectives, topical anesthetics, anti-inflammatory and analgesic agents, antifungal agents, coronaryvasodilators, antiviral agents, miotics and anticholinergics, mydriatic agents, an- tiglaucoma agents, antihistaminics, biogenic peptides and cosmetic agents At room temperature, such a formulation is in the sol form, which is converted into a gel form at a temperature about the body temperature and thus the application onto eye, skin and mucous membranes of the body cavities as well as the improved biopharmaceutical usefulness are made possible.
Kofler Bojan
Kramaric Anton
Resman Aleksander
Zmitek Janko
D.d. Lek Tovarna Farmacevtskih In Kemicnih Izdelkov
Sim & Mcburney
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