Thermoreversible hydrogels comprising linear copolymers and...

C - Chemistry – Metallurgy – 08 – F

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C08F 220/60 (2006.01) B01D 57/02 (2006.01) C08F 251/00 (2006.01) C08F 271/02 (2006.01) C08L 33/26 (2006.01) G01N 27/447 (2006.01)

Patent

CA 2243601

Thermoreversible hydrogels comprising non-ionic, linear copolymers, and methods of their use in electrophoresis, are provided. The subject copolymers comprise polyacrylamide backbones, where a portion of the acrylamide monomeric units comprise hydrogen bonding groups as N-substituents. Combination of the subject copolymers with an aqueous phase provides thermoreversible hydrogels which find use as separation media in electrophoretic applications.

L'invention concerne des hydrogels thermoréversibles contenant des copolymères non ioniques linéaires et leurs procédés d'utilisation en électrophorèse. Les copolymères objets de l'invention comprennent des squelettes de polyacrylamide, dans lesquels une partie des unités monomères d'acrylamide contiennent comme substituants N des groupes de liaison hydrogène. La combinaison de ces copolymères avec une phase aqueuse permet d'obtenir des hydrogels thermoréversibles qui trouvent leur utilisation en tant que milieux de séparation dans des applications électrophorétiques.

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