Thermoreversible immuno-adjuvant emulsion

Details Thermoreversible immuno-adjuvant emulsion Thermoreversible immuno-adjuvant emulsion

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/107 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2613732

The invention relates to an oil-in-water adjuvant emulsion including at least squalene, an aqueous solvent, a nonionic surfactant which is polyoxyethylene alkyl ether and a thermoreversible hydrophobic nonionic surfactant, in which adjuvant the size of 90 % of the oil droplet volume distribution is less than 200 nm. The invention also relates to a method of preparing an immunogenic composition, wherein at least one vaccine antigen is mixed with an oil-in- water emulsion. The invention is characterised in that the oil-in-water emulsion is obtained via a temperature-variation phase inversion method.

L'invention a pour objet une émulsion adjuvante huile-dans-eau comprenant au moins : du squalène, un solvant aqueux, un tensioactif non ionique qui est un polyoxyéthylène alkyl ether, un tensioactif non ionique hydrophobe, thermoréversible, et dont 90 % de la population volumique des gouttes d'huile a une taille inférieure à 200 nm. L'invention a également pour objet un procédé de préparation d'une composition immunogène selon lequel on mélange au moins un antigène vaccinal avec une émulsion huile-dans-eau, caractérisé en ce qu'on obtient l~émulsion huile-dans-eau par un procédé d'inversion de phase par variation de la température.

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