Thermosensitive cyclotriphosphazene-platinum complex...

C - Chemistry – Metallurgy – 07 – F

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C07F 15/00 (2006.01) A61K 31/28 (2006.01) C07F 9/00 (2006.01) C07F 9/6593 (2006.01)

Patent

CA 2388334

The present invention provides a novel thermosensitive cyclotriphosphazene- platinum complex conjugates represented by Formula (1) wherein m is a repeating unit of poly(alkoxyethylene glycol) selected from the integers 2, 7 and 12; n represents the length of the alkyl chain selected from the integers 0, 1, 2 and 3; x represents the length of the anionic amino acid residue selected from the integers 0 (amino malonic acid derivatives), 1 (aspartic acid derivatives) and 2 (glutamic acid derivatives); A2 is a bidentate chelating diamine selected from the group consisting of 2,2-dimethyl-1,3- propanediamine (dmpda), trans(~)-1,2-diaminocyclohex- ane (dach) and 1,1-diaminomethylcyclohexane (dmach).

L'invention concerne un nouveau conjugué complexe thermosensible de cyclotriphosphazène-platine représenté par la formule 1, dans laquelle m désigne un motif de poly(alcoxyéthylène glycol) sélectionné dans les entiers 2, 7 et 12; n désigne la longueur de la chaîne alkyle sélectionnée dans les entiers 0, 1, 2 et 3; x désigne la longueur du reste d'acide aminé anionique sélectionnée dans les entiers 0 (dérivés d'acide aminé malonique), 1 (dérivés d'acide aspartique) et 2 (dérivés d'acide glutamique); A2 désigne une diamine chélatante bidentée sélectionnée dans le groupe comprenant 2,2-diméthyl-1,3-propanédiamine (dmpda), trans(+/-)-1,2-diaminocyclohexane (dach) et 1,1-diaminométhylcyclohexane (dmach).

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