A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/19 (2006.01) C08B 37/00 (2006.01) C08L 5/08 (2006.01)
Patent
CA 2634479
The aqueous thermosetting neutralized chitosan composition, forming a phosphate-free transparent hydrogel at a temperature higher than 5°C, comprises 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70 %, neutralized with an hydroxylated base, and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and polyols derived from polyoses. Said composition is useful for the preparation of an injectable formulation.
L'invention concerne une composition aqueuse thermodurcissable de chitosan neutralisé formant un hydrogel transparent exempt de phosphate à une température supérieure à 5 °C, ladite composition comprenant de 0,1 à 5,0 % p/p, par rapport à la composition totale, d'un chitosan désacétylé ayant un poids moléculaire supérieur ou égal à 100 kDa et un degré de désacétylation compris entre 40 et 70 %, neutralisé avec une base hydroxylée, et de 1 à 30 % p/p, par rapport à la composition totale, d'un agent complexant choisi parmi les polyoses et les polyols dérivés de polyoses. Ladite composition est utile pour la préparation d'une formulation injectable.
Caratti-Besson Virginie
Gurny Robert
Jordan Olivier
Schuetz Yannic
Laboratoire Medidom S.a.
Smart & Biggar
Universite de Geneve
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