C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/04 (2006.01) C12N 15/53 (2006.01) C12Q 1/32 (2006.01)
Patent
CA 2581226
The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoaceticus s-GDH wild-type sequence (SEQ ID NO: 2), it also discloses genes encoding such mutant s-GDH, and different applications of these sGDH mutants, particularly for determining the concentration of glucose in a sample.
La présente invention concerne une protéine mutante de GDH dépendant de PQQ caractérisée en ce que l'acide aminé lysine est présent dans au moins une des positions 122 et 124, ces positions correspondant aux positions d'acide aminé connues par la séquence de <i>A. calcoaceticus </i>s-GDH de type sauvage (SEQ ID NO: 2). L'invention concerne également des gènes codant pour de tels mutants de GDH, ainsi que différentes applications de ces mutants de GDH, en particulier pour la détermination de la concentration de glucose dans un échantillon.
Boenitz-Dulat Mara
Kratzsch Peter
Schmuck Rainer
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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