Thermotherapy via targeted delivery of nanoscale magnetic...

A - Human Necessities – 61 – N

Patent

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A61N 2/02 (2006.01) A61N 1/40 (2006.01)

Patent

CA 2453676

Disclosed are therapeutic methods for the treatment of diseased, disease- causing, or undesirable tissue or material that involve the administration of a thermotherpeutic magnetic composition, which contains single-domain magnetic particles attached to a target-specific ligand, to a patient and the application of an alternating magnetic field to inductively heat the thermotherapeutic magnetic composition. Also disclosed are methods for administration of the thermotherapeutic magnetic composition. These therapeutic methods may be used where the predetermined target is associated with a disease, such as cancer, diseases of the immune system, pathogen-borne diseases, obesity, hormone-related diseases, Alzheimer's disease, disease precursor, and undesirable materials, such as undesirable adipose tissue, reactions to organ transplants, HIV infected cells, polypeptides receptors, blood clots, and low density lipoproteins.

L'invention se rapporte à des méthodes de traitement de tissus ou de matières malades, indésirables ou provoquant une maladie. Ces méthodes consistent à administrer, à un patient, une composition magnétique thermothérapeutique comprenant des particules magnétiques à moment unique attachées à un ligand à cible spécifique, ainsi qu'à appliquer un champ magnétique alternatif afin de chauffer par induction la composition magnétique thermothérapeutique. L'invention concerne également des procédés d'administration de la composition magnétique thermothérapeutique. Ces méthodes thérapeutiques peuvent être utilisées à l'endroit où la cible prédéterminée est associée à la maladie, telle qu'un cancer, des maladies du système immunitaire, des maladies transmises par des agents pathogènes, l'obésité, des maladies hormonales, la maladie d'Alzheimer, le précurseur d'une maladie, et des matières indésirables, telles que des tissus adipeux indésirable, des réactions à des transplantations d'organes, des cellules infectées par le VIH, des récepteurs polypeptidiques, des caillots sanguins, et des lipoprotéines de faible densité.

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