C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/54 (2006.01)
Patent
CA 2147033
This invention provides thiadiazinone derivatives represented by the following formula (I) Image ( I ) wherein R1 represents hydrogen atom or C1-C5 alkyl, R2 represents 5- or 6-membered heterocyclic ring having 1-3 nitrogen atoms, a oxygen atom, one sulfur atom, 1-3 nitrogen atoms and one oxygen atom, or 1-3 nitrogen atoms and one sulfur atom and each ring of which may optionally be substituted by at least one substituent selected from the group consisting of C1-C5 alkyl, cyano, hydroxy, C1-C5 alkoxy, amino, C1-C5 alkylamino, C2-C6 dialkylamino, C2-C5 acylamino, carboxyl, C2-C5 alkoxycarbonyl and carbamoyl; or pharmaceutically acceptable salts thereof. The compounds according to the present invention have an excellent cardiotonic activity, and are useful as active ingredients of cardiotonic drug.
Abe Yuji
Furuya Rikizo
Okushima Hiromi
Kirby Eades Gale Baker
Mitsubishi Chemical Corporation
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