C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/10 (2006.01) A61K 31/433 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2654722
The present invention relates to Thiadiaz.sigma.le Compounds having, for examples the Formula; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase- related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age- related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering- an effective dose of a Thiadiazole Compound to a mammal in need thereof.
La présente invention concerne des composés de thiadiazole; des compositions comprenant une dose efficace d'un composé de thiadiazole; et des procédés de traitement ou de prévention d'un trouble lié aux métalloprotéinases tel qu'un trouble arthritique, l'ostéoarthrite, le cancer, la polyarthrite rhumatoïde, l'asthme, la maladie pulmonaire obstructive chronique, l'athérosclérose, la dégénérescence maculaire liée à l'âge, l'infarctus du myocarde, une ulcération cornéenne, une maladie de la surface de l'AEil, l'hépatite, un anévrisme aortique, la tendinite, un trouble du système nerveux central, la cicatrisation anormale, l'angiogenèse, la resténose, la cirrhose, la sclérose en plaques, la glomérulonéphrite, la maladie homologue, le diabète, une maladie entérique inflammatoire, le choc, la dégénérescence des disques intervertébraux, l'accident vasculaire cérébral, l'ostéopénie ou une maladie parodontique, comprenant l'administration d'une dose efficace d'un composé de thiadiazole à un mammifère nécessitant un tel traitement.
Bursavich Matthew G.
Gilbert Adam M.
Lombardi Sabrina
Smart & Biggar
Wyeth
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