Thiadiazole derivatives for the treatment of neuro...

Details Thiadiazole derivatives for the treatment of neuro... Thiadiazole derivatives for the treatment of neuro...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2641453

This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an .alpha.-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.

De manière spécifique, la présente invention concerne des dérivés substitués de 1,2,4-thiadiazole destinés à être utilisés dans le traitement d'une alpha-synucléopathie telle que la maladie de Parkinson, la maladie à corps de Lewy diffuse, la lésion cérébrale traumatique, la sclérose latérale amyotrophique, la maladie de Niemann-Pick , le syndrome de Hallervorden-Spatz, le syndrome de Down, la dystrophie neuroaxonale, l'atrophie systématisée multiple et la maladie d'Alzheimer.

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