C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/433 (2006.01) A61K 31/4365 (2006.01) A61K 31/4725 (2006.01) A61P 3/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 285/135 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2693473
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
La présente invention concerne des composés thiazoles de formule I et de formule II ainsi que des compositions contenant lesdits composés utiles pour traiter des maladies médiées par la protéine kinase B (PKB), dans lesquelles les variables sont tels que définis dans la description. L'invention concerne également l'utilisation thérapeutique de tels composés thiazoles et des compositions en contenant dans le traitement d'états morbides associés à une croissance cellulaire anormale, le cancer, l'inflammation, et les troubles métaboliques.
Allen John G.
Bourbeau Matthew P.
Dominguez Celia
Fotsch Christopher H.
Han Nianhe
Amgen Inc.
Gowling Lafleur Henderson Llp
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