Thiadiazoledioxides and thiadiazoleoxides as cxc- and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 285/10 (2006.01) A61K 31/433 (2006.01) A61K 31/4436 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2501535

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

La présente invention concerne de nouveaux composés représentés par la formule générale (IA) et certains de ses sels et solvates pharmaceutiquement admis. Avec le substituant A, il s'agit essentiellement de groupes hétéroaryle, aryle, hétérocycloalkyle, cycloalkyle, aryle, alkynyle, alcényle, aminoalkyle, alkyle ou amino. Avec le substituant B, il s'agit essentiellement de groupes aryle et hétéroaryle. L'invention concerne également un procédé permettant de traiter, par administration d'un composé représenté par la formule générale (IA), des maladies où intervient une médiation chimiokinique telle que cancer, angiogenèse, maladies oculaires angiogènes, maladies pulmonaires, sclérose en plaques, arthrite rheumatoïde, arthrose, lésions d'accidents cérébrovasculaires et de reperfusion, douleur aiguë, douleur inflammatoire aiguë et chronique, et douleur neuropathique.

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