Thiadiazolidinones as gsk-3 inhibitors

Details Thiadiazolidinones as gsk-3 inhibitors Thiadiazolidinones as gsk-3 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 285/08 (2006.01) A61K 31/433 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) C07D 417/10 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2559740

Provided are thiadiazolidine compounds of Formula (I) wherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a -C(O)- and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury.

La présente invention a trait à des composés de formule (I), dans laquelle : R¿1? est un groupe organique ayant au moins 8 atomes choisis parmi C et O, qui n'est pas en liaison directe avec l'atome d'azote via un -C(O)- et comportant au moins un noyau aromatique, et leurs compositions pharmaceutiques. Ces composés sont des inhibiteurs sélectifs de la GSK-3 et présentent une biodisponibilité améliorée. Ils sont utiles pour le traitement de maladies liées à la GSK-3, comprenant entre autres la maladie d'Alzheimer, le diabète de type II, la dépression et la lésion cérébrale.

Affiliated with

Also associated with

Rating

Thiadiazolidinones as gsk-3 inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiadiazolidinones as gsk-3 inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiadiazolidinones as gsk-3 inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1361122