Thiadiazolyl and oxadiazolyl phenyl oxazolidinone...

Details Thiadiazolyl and oxadiazolyl phenyl oxazolidinone... Thiadiazolyl and oxadiazolyl phenyl oxazolidinone...

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/42 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2294293

The present invention provides thiadiazolyl and oxadiazolyl phenyl oxazolidinone compounds of formula (I) wherein Q is thiadiazolyl or oxadiazolyl; wherein X1 and X2 are independently hydrogen, fluorine, or chlorine; and wherein R1 is, for example, -COCH3 or -COCH2CH3. These compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive and gram-negative aerobic bacteria.

Cette invention se rapporte à des composés phényloxazolidinones de thiadiazolyle et d'oxadiazolyle, représentés par la formule (I) dans laquelle Q est thiadiazolyle ou oxadiazolyle; X?1¿ et X?2¿ sont indépendamment hydrogène, fluor ou chlore; et R?1¿ est, par exemple, -COCH¿3? ou -COCH2CH¿3?. Ces composés s'avèrent être des agents antimicrobiens utiles, efficaces à l'encontre d'un certain nombre d'agents pathogènes s'attaquant à l'homme ou aux animaux, notamment des bactéries aérobies gram positives et gram négatives.

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