Thiadiazolyl urea or thiourea derivatives for antiviral...

A - Human Necessities – 61 – K

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A61K 31/433 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2368615

A pharmaceutical composition that inhibits or slows the growth of viruses in animals, particularly in mammals, is disclosed. This same composition can be used to treat viral infections, particularly hepatitis C, herpes simplex, Kaposi's sarcoma and HIV. The composition preferably comprises from about 10 mg to about 6000 mg of a (5- aryl-1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl-1,2,4,-thiadiazol)-3-yl urea derivative of formula (I), wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 0-4, R1 is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula -O(CH2)y CH3 wherein y is from 1 to 6, or a pharmaceutically acceptable acid addition salt or prodrug thereof. The preferred compound is (5-phenyl-1,2,4- thiadazol-3-yl) thiourea.

L'invention concerne une composition pharmaceutique inhibant ou ralentissant la croissance de virus chez des animaux, notamment chez des mammifères. On peut utiliser cette composition pour traiter des infections à virus, notamment l'hépatite C, l'herpès, le sarcome de Kaposi et le VIH. Cette composition comprend, de préférence, environ 10 à environ 6000 mg d'un dérivé de (5-aryl-1,2,4-thiadiazol)-3-yl thiourée ou d'un dérivé de (5-aryl-1,2,4,-thiadiazol)-3-yl-urée correspondant à la formule (I) dans laquelle X représente oxygène ou soufre, R représente hydrogène ou alkyle possédant 1 à 3 atomes de carbone, n vaut 0 à 4, R1 représente indépendamment hydrogène, alkyle possédant 1 à 7 atomes de carbone, chloro, bromo ou fluoro, oxychloro, alcoxy possédant la formule -O(CH2)yCH3 où y vaut 1 à 6. L'invention concerne également un sel d'addition d'acide de ce composé, acceptable sur le plan pharmacologique, ou un promédicament de ce composé. Le composé que l'on préfère est une (5-phenyl-1,2,4-thiadazol-3-yl)thiourée.

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