Thianaphthene derivatives, their production and use

Details Thianaphthene derivatives, their production and use Thianaphthene derivatives, their production and use

C - Chemistry, Metallurgy

07

D

260/305, 260/280

C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1301172

ABSTRACT Compounds of formula (I): Image (I) (wherein n is 0 or 1, R1 and R2 are hydrogen or alkyl, one of A1 and A2 is -Z-Y and the other is -W-COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A2 and hence are useful in the treatment or prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.

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