Thiazide diuretics for antihypertension without diuresis

Details Thiazide diuretics for antihypertension without diuresis Thiazide diuretics for antihypertension without diuresis

A - Human Necessities

61

K

167/204, 167/206

A61K 31/54 (2006.01) A61K 31/74 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1279575

TREATMENT OF HYPERTENSION, COMPOUNDS AND COMPOSITIONS FOR ANTIHYPERTENSION AND DIURESIS ABSTRACT OF THE DISCLOSURE Antihypertension action is achieved without diuresis by administration of a thiazide diuretic in an amount which while being sufficient to achieve antihypertension is insufficient to achieve diuresis. Such administration in a non-diuretic amount is effected in 4-8 consecutive hourly doses to achieve reduction of blood pressure without high urine output. The invention further relates to complexes of thiazides with mixed cation-anion exchange resins, to insoluble basic metal hydroxy thiazide salts, the salts of thiazide with calcium disodium edetate or disodium edetate, to molecular complexes of thiazides with long chain polymers such as hydroxy alkyl cellulose polymers, carboxy methyl cellulose and polyvinylpyrrolidone, to beta-adrenergic blocking amine-thiazide salts and to amiloride thiazide salts.

468042

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