Thiazine (or oxazine) derivatives and preparation thereof

Details Thiazine (or oxazine) derivatives and preparation thereof Thiazine (or oxazine) derivatives and preparation thereof

C - Chemistry, Metallurgy

07

D

167/212, 167/215

C07D 279/14 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 265/34 (2006.01) C07D 265/36 (2006.01) C07D 279/16 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2035147

- 71 - Abstract of the Disclosure: Thiazine (or oxazine) derivatives of the formula [I]: Image [I] wherein R1 and R2 are both H or form a naphthalene ring together with the benzene ring; R3 and R4 are both H, or one of them is halogen and another is H; X is S or O; R5 and R6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substi- tuted phenyl, v) naphthyl, vi) lower alkyl which is substi- tuted by substituted or unsubstituted phenyl, or vii) S- containing heterocyclic group; one of Z1 and Z2 is O and another is H2; A is lower alkylene; R7 and R8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubsti- tuted phenyl, or both form together N-containing heterocyclic group; provided that when both of R1 and R2 are H, Z2 is O and either one of R5 and R6 is substituted phenyl, naphthyl or S- containing heterocyclic group, or their salts, which have calcium antagonistic activity within the cerebral tissues and are useful for prophylaxis and treatment of ischemic encephalopathia and/or cerebral neurocyte dyscrasia, and process for preparing said compounds.

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