C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/243.22, 260/
C07D 513/04 (2006.01)
Patent
CA 1169424
ABSTRACT The specification describes novel thiazinobenz- midazole derivatives represented by the general formula: Image wherein R1, R2 and X represent a wide variety of substi- tuent groups respectively. The above thiazinobenzimidazole derivatives may be prepared by reacting corresponding 2- hydroxymethyl thiazinobenzimidazole derivatives with cor- responding reactive derivatives of carboxylic acids or hal- ogenides or by reacting 2-p-toluenesulfonyloxymethyl-thiazino- benzimidazole derivatives with sodium azides, thiols, phenols or amines. The above thiazinobenzimidazole deriv- atives wherein X is OH may be prepared by reducing their corresponding 2-alkoxycarbonyl derivatives. Where X re- presents a p-toluenesulfonyloxy group, the thiazinobenz- imidazole derivatives may be obtained by reacting correspond- ing 2-hydroxymethyl-thiazinobenzimidazole derivatives with p-toluenesulfonyl chloride. Where X stands for an N-sub- stituted 2-(homo)piperazinomethyl group, 2-(homo)piperazino- methyl-thiazinobenzimidazole derivatives are reacted with reactive compounds to introduce the desired substituent groups. The thiazinobenzimidazole derivatives according to this invention are useful as medicaments for circulatory systems.
372278
Eto Hiromichi
Kohmoto Teruo
Kouda Tadayuki
Kuraishi Tadayuki
Nakashima Toshiaki
Gowling Lafleur Henderson Llp
Ss Pharmaceutical Co. Ltd.
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