Thiazole-amide compounds and compsitions as protein kinase...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 417/14 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) C07D 277/56 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2593803

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, FGFR3, PDGFR.beta. and b-Raf kinases.

L'invention concerne une nouvelle catégorie de composés, des compositions pharmaceutiques les contenant, ainsi que des méthodes d'utilisation de ces composés dans le traitement ou la prévention de maladies ou de troubles associés à une activité kinase anormale ou déréglée, en particulier des maladies ou des troubles impliquant une activation anormale des kinases Abl, Bcr-Abl, FGFR3, PDGFRß et b-Raf.

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