Thiazole and oxazole derivatives

Details Thiazole and oxazole derivatives Thiazole and oxazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 9/04 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 277/26 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2423885

Compounds of the general formula (I), their optical isomers or prodrugs, pharmaceutically acceptable salts of the compounds, the isomers, or the prodrugs, or solvates of the same; and metalloprotease inhibitors containing the compounds, the optical isomers, the prodrugs, the salts, or the solvates: (I) wherein R1 is hydroxyl or the like; R2 is optionally substituted lower alkyl or the like; R3 is hydrogen or the like; R4 is optionally substituted arylene or the like; R5 is a group of formula (II) or (III): (III) and R6 is optionally substituted aryl or the like.

La présente invention concerne des composés représentés par la formule générale (I), leurs isomères optiques ou promédicaments, certains de leurs sels pharmaceutiquement admis, ainsi que les isomères, promédicaments ou solvates de ces sels. L'invention concerne également des inhibiteurs des métalloprotéases à base de ces composés, de leurs isomères optiques, de leurs promédicaments, de leurs sels ou de leurs solvates. Dans cette formule générale, R?1¿ est hydroxyle ou analogue. R?2¿ est alkyle inférieur éventuellement substitué ou analogue. R?3¿ est hydrogène ou analogue. R?4¿ est arylène éventuellement substitué ou analogue. R?5¿ est un groupe représenté par la formule (II) ou (III). Enfin, R?6¿ est aryle éventuellement substitué ou analogue.

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