Thiazole and oxazole derivatives that modulate ppar activity

Details Thiazole and oxazole derivatives that modulate ppar activity Thiazole and oxazole derivatives that modulate ppar activity

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 277/26 (2006.01)

Patent

CA 2476580

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

L'invention porte sur des composés qui modifient l'activité du récepteur PPAR. Cette invention concerne des sels pharmaceutiquement acceptables de ces composés, des compositions pharmaceutiquement acceptables contenant ces composés ou leurs sels, et des procédés utilisant ces composés en tant qu'agents thérapeutiques dans le traitement ou la prévention de l'hyperlipidémie et de l'hypercholestérolémie chez un mammifère. L'invention porte également sur un procédé de fabrication des composés susmentionnés.

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