Thiazole and oxazole derivatives which modulate ppar activity

Details Thiazole and oxazole derivatives which modulate ppar activity Thiazole and oxazole derivatives which modulate ppar activity

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) C07D 277/24 (2006.01) C07D 277/26 (2006.01)

Patent

CA 2478520

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses methods for making the disclosed compounds.

L'invention a trait à des composés qui modifient l'activité de PPAR ; à des sels pharmaceutiquement acceptables de ceux-ci, à des compositions pharmaceutiquement acceptables contenant lesdits composés ou leurs sels, et à des procédés d'utilisation de ceux-ci comme agents thérapeutiques pour traiter ou prévenir l'hyperlipidémie et l'hypercholestérolémie chez un mammifère ; et à des procédés de fabrication de ces composés.

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