C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/5377 (2006.01) A61P 31/12 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07D 277/42 (2006.01) C07D 413/12 (2006.01) C07D 491/10 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2452609
Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.
L'invention concerne des composés d'aminothiazole comprenant un benzamide monosubstitué ou disubstitué de la formule (I), et leurs sels pharmaceutiquement acceptables, leurs promédicaments pharmaceutiquement acceptables, leurs métabolites pharmaceutiquement actifs, et les sels pharmaceutiquement acceptables desdits métabolites. Ces agents modulent et/ou inhibent la prolifération cellulaire et l'activité des protéines kinases, et peuvent être utilisés comme produits pharmaceutiques pour traiter des malignités ou autre affections.
Alegria Larry Andrew
Bleckman Ted Michael
Chong Wesley K. M.
Chu Shao Song
Duvadie Rohit K.
Agouron Pharmaceuticals Inc
Smart & Biggar
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