Thiazole compound and use thereof

Details Thiazole compound and use thereof Thiazole compound and use thereof

C - Chemistry, Metallurgy

07

D

C07D 277/24 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/498 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 17/00 (2006.01) A61P 43/00 (2006.01) C07D 277/20 (2006.01) C07D 277/30 (2006.01) C07D 417/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2566625

A novel thiazole compound represented by the general formula (1), an optical isomer thereof, or a salt of either. They have specific inhibitory activity against phosphodiesterase 4. [Chemical formula 1] (1) In the formula, R1 represents di(C1-6 alkoxy)phenyl; R2 represents any of the following groups (a) to (t): (a) phenyl, (b) naphthyl, (c) pyridyl, (d) furyl, (e) thienyl, (f) isoxazolyl, (g) thizolyl, (h) pyrrolyl, (i) imidazolyl, (j) tetrazolyl, (k) pyrazinyl, (l) thienothienyl, (m) benzothienyl, (n) indolyl, (o) benzimidazolyl, (p) indazolyl, (q) quinolyl, (r) 1,2,3,4-tetrahydroquinolyl, (s) quinoxanyl, and (t) 1,3-benzodioxolyl; and A represents any of the following groups (i) to (vi): (i) -CO-B (B represents C1-6 alkylene), (ii) -CO- Ba- (Ba represents C2-6 alkenylene), (iii) -CH(OH)-B-, (iv) -COCH(COOR3)-Bb- (R3 represents C1-6 alkyl and Bb represents C1-6 alkylene), and (v) -Bc- (Bc represents C2-6 alkylene).

Nouveau composé thiazole représenté par la formule générale (1), isomère optique de celui-ci ou sel de l'un ou l'autre. Ils ont une activité d'inhibition spécifique vis-à-vis de la phosphodiestérase 4. [Formule chimique 1] (1) Dans la formule, R1 représente un di(alcoxy en C¿1-6?)phényle ; R2 représente l'un quelconque des groupes (a) à (t) suivants : (a) phényle, (b) naphtyle, (c) pyridyle, (d) furyle, (e) thiényle, (f) isoxazolyle, (g) thizolyle, (h) pyrrolyle, (i) imidazolyle, (j) tétrazolyle, (k) pyrazinyle, (l) thiénothiényle, (m) benzothiényle, (n) indolyle, (o) benzimidazolyle, (p) indazolyle, (q) quinolyle, (r) 1,2,3,4-tétrahydroquinolyle, (s) quinoxanyle et (t) 1,3-benzodioxolyle ; et A représente l'un quelconque des groupes (i) à (vi) suivants : (i) -CO-B (B représente un alkylène en C¿1-6?), (ii) -CO-Ba- (Ba représente un alcénylène en C¿2-6?), (iii) -CH(OH)-B-, (iv) -COCH(COOR3)-Bb- (R3 représente un alkyle en C¿1-6? et Bb représente un alkylène en C¿1-6?) et (v) -Bc- (Bc représente un alkylène en C¿2-6?).

Affiliated with

Also associated with

Rating

Thiazole compound and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiazole compound and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiazole compound and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1504636