Thiazole compounds as protein kinase b (pkb) inhibitors

Details Thiazole compounds as protein kinase b (pkb) inhibitors Thiazole compounds as protein kinase b (pkb) inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 277/42 (2006.01) C07D 277/54 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2636077

The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

La présente invention concerne des composés thiazole de formule (I) et formule (II), ainsi que des compositions les comprenant utiles pour traiter les maladies liées à l'activité de la protéine kinase B (PKB). Dans ces formules, les variables sont telles que définies dans la description. L'invention concerne également l'utilisation thérapeutique desdits composés thiazole et de compositions les contenant pour le traitement d'états maladifs associés à la prolifération anormale des cellules, aux cancers, aux inflammations et aux troubles métaboliques.

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