C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/277
C07D 277/20 (2006.01) A61K 31/395 (2006.01) C07D 277/48 (2006.01) C07D 417/02 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2007133
ABSTRACT There are described compounds of the formula: Image wherein R1 and R2 are each halogen, lower alkyloxy, lower alkylthio or lower alkylsulfinyl, A is lower alkylene, carbonyl or single bond, and Z is heterocyclic group which may have suitable substituent(s), a group of the formula : Image in which R3 and R4 are each hydrogen, lower alkyl which may have heterocyclic group or piperidyl which may have suitable substituent(s), or a group of the formula : Image in which (1) R5, R6 and R7 are each hydrogen, lower alkyl or cyclo(lower)alkyl; (2) R5 is hydrogen, lower alkyl or cyclo(lower)- alkyl, and R6 and R7 are linked together with the attached nitrogen atom to form heterocyclic group which may have suitable substituent(s); or (3) R5 and R6 are linked together to form lower alkylene, and R7 is hydrogen; provided that when Z is a group of the formula : Image wherein R3 and R4 are each as defined above, then A is lower alkylene or carbonyl, and pharmaceutically acceptable salt thereof. These compounds are useful for their antithrombic vasodilating, antiallergic, anti-inflammatory and 5- lipoxygenase inhibitory activies. The preparation of these compounds as well as preparation containing them and their uses are also disclosed.
Nishino Shigetaka
Takasugi Hisashi
Tanaka Akito
Fujisawa Pharmaceutical Co. Ltd.
Nishino Shigetaka
Swabey Ogilvy Renault
Takasugi Hisashi
Tanaka Akito
LandOfFree
Thiazole compounds, processes for the preparation thereof... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thiazole compounds, processes for the preparation thereof..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiazole compounds, processes for the preparation thereof... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2032908