Thiazole compounds useful as inhibitors of protein kinase

Details Thiazole compounds useful as inhibitors of protein kinase Thiazole compounds useful as inhibitors of protein kinase

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61P 3/10 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 417/14 (2006.01) C07D 487/10 (2006.01) C07D 521/00 (2006.01) C07F 7/18 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2446756

The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatement of various protein kinase mediated disorders.

L'invention porte sur un composé de formule (I) ou ses dérivés pharmacocompatibles inhibiteurs des protéines kinases, et en particulier des protéines kinases GSK3, Aurora2, et Syk de mammifères. L'invention porte également sur des préparations pharmacocompatibles contenant lesdits composés, et sur des procédés d'utilisation de ces composés et préparations pour le traitement de différents troubles médiés par les protéines kinases.

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