Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 277/40 (2006.01) A61K 31/425 (2006.01) C07D 209/48 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2074175

2074175 9110656 PCTABS00006 New thiazole derivatives which are a substituted 4- or 5-(.omega.-aminoalkyl)thiazole with formula (1), wherein X represents a nitrogen atom and Y represents a sulphur atom or alternatively X represents a sulphur atom and Y represents a nitrogen atom, n is 1-6, R1 represents a straight or branched alkyl group containing 1-4 carbon atoms and R2 represents an amino group, a process for the preparation of said compounds by ring closure of a 3-bromo-.omega.-phthalimidoalkan-2-one with thiourea under mild conditions, followed by hydrazinolysis or hydrolysis with diluted hydrochloric acid of the resulting phthalimido derivatives and medicaments containing said derivates with formula (1) for the treatment of congestive heart diseases or for the treatment of allergic disorders.

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