Thiazole derivatives

Details Thiazole derivatives Thiazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/426 (2006.01) A61P 25/00 (2006.01) C07D 277/42 (2006.01) C07D 277/46 (2006.01) C07D 277/48 (2006.01) C07D 277/62 (2006.01) C07D 277/64 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2385692

The invention provides compounds of formula 1 (see formula I) wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission are described. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with bums, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.

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